Endocrine Abstracts

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...

Background: Small-bowel neuroendocrine tumours (SB-NET) commonly metastasise despite most being low grade. The NET nomogram developed, estimates 5- and 10-year survival in SB-NET by allocating scores for 15 clinicopathological parameters. We comparatively evaluated the prognostic power of this nomogram, the WHO/ENETS grading and AJCC/UICC staging systems.Methods: Patients with histologically-confirmed SB-NET were identified from databases at two tertiary...

Background and aim: The relationship between sarcopenia and overt cortisol excess as in Cushing’s syndrome is well-known. However, only a few studies investigated the relationship between autonomous cortisol secretion (ACS) in adrenal incidentalomas and skeletal muscle mass. The aims of our study were to analyze the skeletal muscle mass in patients with adrenal incidentalomas and to investigate the correlations with hormonal data.Methods: We enrolle...

Background and aims: Combining systemic immunomodulation with disease-relevant antigens could provide longer-term solutions for preventing and even reversing autoimmune type 1 diabetes (T1D). Our team established that a combination therapy (CT), composed of a short-course low-dose anti-CD3 treatment with oral delivery of genetically-modified Lactococcus lactis (L. lactis) bacteria secreting full proinsulin plus the anti- inflammatory cytokine IL-10 (LL-PINS+I...

Background: We aimed to evaluate the added information provided by 68Ga-DOTATATE PET after two cycles of peptide receptor radionuclide therapy (PRRT) in patients with somatostatin receptor (SSTR)-expressing neuroendocrine tumors (NET).Methods: In this retrospective study, 105 patients (54 women and 51 men, 62.5&pm;10.5-year-old) with progressive NET treated with at least two cycles of 177Lu-DOTATATE were included. All patients had <...

Background: Adrenal lipid poor adenoma (LPA) and adrenocortical cancer (ACC) may overlap in computerized tomography (CT). Radiomics recently emerged as new tool for malignant behavior identification.Aim: To assess radiomics utility for identification of ACC and LPA in adrenocortical masses with unenhanced (UE) CT scan attenuation≥10 Hounsfield Unit (HU).Methods: We retrospectively enrolled 50 patients, 38 radiologically defin...

Background: Adrenal insufficiency patient (AIP) care is mostly based on symptoms or clinical signs of inadequate glucocorticoid replacement treatment (GRT). Salivary cortisol (F) and cortisone (E) recently emerged as new tools for AIP management, although poorly employed in clinical practice.Aim: To assess associations between salivary glucocorticoid measures and life quality, anxiety depressive symptoms, sleep quality in AIP.Metho...

Aim: To analyze the prevalence of anxiety and depression in a large cohort of adults affected by autoimmune diabetes and to identify the associated factors, stratifying them according to sex.Methods: We administered to 553 patients with autoimmune diabetes the questionnaires: Hospital Anxiety and Depression Scale (HADS), Diabetes Distress Scale, Diabetes-related Quality of Life and Diabetes Treatment Satisfaction Questionnaire. We excluded 119 patients w...

Introduction: Somatotropinomas are benign pituitary tumors with heterogeneous biological and clinical behavior. The tumor microenvironment (TME) is an environment generated by the interaction between tumor cells and the host immune system. It affects both the behavior of the tumor and the outcome of the therapy. The GNAS gene encodes the alpha subunit of G proteins associated with hormone receptors such as TSH, PTH, GHRH, FSH/lH, ACTH. Mutation of this gene has been associated...

Somatotropinomas are benign pituitary tumors, with a heterogenous biological and clinical behavior. Tumor microenvironment reflects the interaction between tumor cells and the host immune system and may regulate tumor behavior and therapy outcome. We develop a scoring system that includes clinical, pathological and immune markers to early identify fg-SRLs resistant acromegaly pts. 43 acromegaly pts were included according the following criteria (1) first line treatment with su...